Friday, February 21, 2014

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What is percutaneous endoscopy gastrostomy (PEG) in children? How is percutaneous endoscopy gastrostomy (PEG) performed in children?

Percutaneous endoscopic gastrostomy (PEG) feeding tubes were first described in 1980 for use in children. PEG feeding tubes are now increasingly used for enteral nutrition for both children and adults. PEG may be used with a jejunal extension. 
PEG feeding is used where patients cannot maintain adequate nutrition with oral intake. However, the simplicity of PEG feeding has led to some to be concerned about its use when there is little or no clinical benefit.
There are sometimes ethical factors to consider (see 'Ethical dilemmas', below). Several court cases have considered use of PEG feeding in patients who have lost the capacity for self-determination.

Indications
In the past, it was considered that the lower limit of body weight to insert PEG tubes should be 10 kg but PEG has been reported to be inserted safely in infants with a weight as low as 2.3 kg. The use of PEG may be indicated for children with:
· Neurological disorders with inability to swallow or dysphagia.
· Craniofacial abnormalities.
· Oncology problems with malnutrition.
· Other clinical conditions that lead to wasting and malnutrition - eg, chronic kidney disease, cystic fibrosis, metabolic problems, chronic infection such as HIV, cardiac disorders, short bowel syndrome and Crohn’s disease.

Contra-indications to PEG 
·Absolute contra-indications for using PEG in children are bleeding disorders, severe 
ascites, peritonitis, pharyngeal or oesophageal obstruction and during periods of acute 
severe illness.
·Relative contra-indications for use of PEG include acute severe illness, 
anorexia, previous gastric surgery, peritonitis, ascites, and gastric outlet obstruction.

Cautions
·Infection: active systemic infection increases the risk of early mortality and morbidity 
post-PEG placement. Elevation of serum CRP is the most accurate prognostic indicator of 
poor outcome.
·Other comorbidity: poorer outcome, with increased PEG site and systemic infection 
have been reported in patients with diabetes mellitus, chronic obstructive pulmonary 
disease and low albumin levels.
·Ventriculo-peritoneal shunts: placement of PEG tubes increases the risk of shunt 
infection but this risk decreases with increased time between shunt insertion and PEG 
insertion. Prophylactic antibiotics may further reduce the infection risk.
·         Anatomical considerations: in patients with severe kyphoscoliosis, the stomach is often intrathoracic. This particularly applies to patients with cerebral palsy. Radiological and endoscopic approaches may be impossible. A combined laparoscopic and endoscopic approach can be tried but this requires a general anaesthetic, which also represents a considerable risk for the patient.

PEG insertion method
·         In children, PEG tube insertion is performed under general anaesthesia. A single dose of intravenous antibiotic is given.
·         After insertion of the gastroscope into the stomach and a gentle insufflation of air, the most transluminant point of indentation on the anterior abdominal wall is marked.
·         After sterilising the skin of the anterior abdominal wall and infiltration of this point with local anaesthesia, a skin incision is made and a trocar with a needle is pushed through into the stomach under complete endoscopic visualisation.
·         A thread or a guide wire is inserted through the trocar after removing the needle and this thread is then snared. The endoscope is then withdrawn with the snare holding the thread.
·         A suitably sized PEG tube is then connected to the thread and the thread is pulled from the skin incision pulling the tube into the patient’s mouth through the oesophagus, to be retained in the stomach by the internal bolster. An external bolster is placed loosely on the skin.
·         The position of the inner opening of the tube should be checked by endoscopy.
·         In the past, commencing use of the tube has been delayed until 24 hours after insertion. There is now evidence that delaying use of the tube has no advantage over early feeding.

Benefits of PEG feeding
Benefits include:
·         It is well tolerated (better than nasogastric tubes).
·         Nutritional status is improved.
·         Ease of usage over other methods (nasogastric or oral feeding) reported by carers.
·         Satisfactory use by home carers.[9]
·         Low incidence of complications.
·         Reduction in aspiration pneumonia associated with swallowing disorders.
·         Cost-effective relative to alternative methods, particularly when reasonably long survival is expected.

Management after insertion
·         Education of carers and patients is essential to reduce tube problems and complications.
·         A number of studies indicate the support and education of patients should be multidisciplinary, involving:
·         Nurses (wound care and ostomy expertise).
·         Dietitians (nutritional advice and support).
·         Ongoing care involves:
·         Inspection and maintainance of the access device (see 'Care of PEG tube', below).
·         Wound care advice.
·         Nutritional support and advice.

Care of PEG tube
This routine care can be performed by the patient and/or the carers with suitable training. After about 10 days following insertion asepsis is not required.
·         Examine the skin for infection/irritation around the site.
·         Note the measuring guide number at the end of the external fixation device.
·         Remove the tube from the fixation device and ease away from the abdomen.
·         Clean the stoma site with sterile saline.
·         Dry the area with gauze.
·         Rotate the gastrostomy tube to prevent adherence to sides of the track.
·         Re-attach the external fixation device to the abdomen.
·         Attach the gastrostomy tube gently to the fixation device and position as before according to the mark/number on the tube.
·         Avoid use of bulky dressings.

Complications
Immediate (within 72 hours):
·         Endoscopy-related:
·         Haemorrhage or perforation.
·         Aspiration.
·         Oversedation.
·         Procedure-related:
·         Ileus.
·         Pneumoperitoneum.
·         Wound infection.
·         Wound bleeding.
·         Injury to the liver, bowel, or spleen.
Delayed:
·         Gastric outlet obstruction.
·         Buried bumper syndrome (migration of the internal bumper of the PEG tube into the gastric or abdominal wall).
·         Dislodged PEG tube.
·         Peritonitis.
·         Peristomal leakage or infection.
·         Skin or gastric ulceration.
·         Blocked PEG tube.
·         Tube degradation.
·         Gastric fistula after removal of the PEG tube.
·         Granulation around site of insertion of the PEG tube.

Prognosis
·         There have been few long-term follow-up studies. Clearly the overall mortality rate after PEG insertion is high because of the underlying medical problems.[13]

·         A five-year prospective study showed few complications from the procedure itself and improved nutritional status.

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